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Article

HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.

Blood - 21 Aug 2014

Fernandez Christian A, Smith Colton, Yang Wenjian, Daté Mihir, Bashford Donald, Larsen Eric, Bowman W Paul, Liu Chengcheng, Ramsey Laura B, Chang Tamara, Turner Victoria, Loh Mignon L, Raetz Elizabeth A, Winick Naomi J, Hunger Stephen P, Carroll William L, Onengut-Gumuscu Suna, Chen Wei-Min, Concannon Patrick, Rich Stephen S, Scheet Paul, Jeha Sima, Pui Ching-Hon, Evans William E, Devidas Meenakshi, Relling Mary V

Abstract excerpt

Asparaginase is a therapeutic enzyme used to treat leukemia and lymphoma, with immune responses resulting in suboptimal drug exposure and a greater risk of relapse. To elucidate whether there is a genetic component to the mechanism of asparaginase-induced immune responses, we imputed human leukoc...

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Identifiers

PMID: 24970932
DOI: 10.1182/blood-2014-03-563742
PMCID: PMC4141516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24970932-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.PMID 24970932Read ↗

Two tagging single-nucleotide polymorphisms to capture HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype associated with asparaginase hypersensitivity.Semantic proximity Read ↗

Class II Human Leukocyte Antigen Variants Associate With Risk of Pegaspargase Hypersensitivity.Semantic proximity Read ↗

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.Semantic proximity Read ↗

HLA Alleles Associated with Asparaginase Hypersensitivity in Childhood ALL: A Report from the DFCI ConsortiumSemantic proximity Read ↗

HLA-DRB1*07:01–HLA-DQA1*02:01–HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemiaSemantic proximity Read ↗

Polymorphisms in GRIA1 gene are a risk factor for asparaginase hypersensitivity during the treatment of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

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Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.Semantic proximity Read ↗

Update on the Use of L-Asparaginase in Infants and Adolescent Patients with Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

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