Article
HLA-DRB1*07:01 is associated with a higher risk of asparaginase allergies.
Blood - 21 Aug 2014
Fernandez Christian A, Smith Colton, Yang Wenjian, Daté Mihir, Bashford Donald, Larsen Eric, Bowman W Paul, Liu Chengcheng, Ramsey Laura B, Chang Tamara, Turner Victoria, Loh Mignon L, Raetz Elizabeth A, Winick Naomi J, Hunger Stephen P, Carroll William L, Onengut-Gumuscu Suna, Chen Wei-Min, Concannon Patrick, Rich Stephen S, Scheet Paul, Jeha Sima, Pui Ching-Hon, Evans William E, Devidas Meenakshi, Relling Mary V
Abstract excerpt
Asparaginase is a therapeutic enzyme used to treat leukemia and lymphoma, with immune responses resulting in suboptimal drug exposure and a greater risk of relapse. To elucidate whether there is a genetic component to the mechanism of asparaginase-induced immune responses, we imputed human leukocyte antigen (HLA) alleles in patients of European ancestry enrolled on leukemia trials at St. Jude Children's Research...
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