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Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium.

Pediatric blood & cancer - 1 Jul 2026

Mason Emily J, Woodhouse John P, Yi Joanna S, Gramatges M Monica, Taylor Olga A, Morales Veronica A, Dhamodharan Shalini, Roberts Marley, Rabin Karen R, Lupo Philip J, Scheurer Michael E, Huynh Van, Mittelman Steven D, Orgel Etan, Brown Austin L

Abstract excerpt

Treatment-associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele was associated with an increased odds of conjugated hyperbilirubinemia...

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Identifiers

PMID: 42084208
DOI: 10.1002/1545-5017.70387
PMCID: PMC13331275

Genes

SOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium.PMID 42084208Read ↗

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