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Article

Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2015

Ben Tanfous Mohsen, Sharif-Askari Bahram, Ceppi Francesco, Laaribi Haithem, Gagné Vincent, Rousseau Julie, Labuda Malgorzata, Silverman Lewis B, Sallan Stephen E, Neuberg Donna, Kutok Jeffery L, Sinnett Daniel, Laverdière Caroline, Krajinovic Maja

Abstract excerpt

PURPOSE: Asparaginase (ASNase) is a standard and critical component in the therapy of childhood acute lymphoblastic leukemia (ALL), but it is also associated with several toxicities. EXPERIMENTAL DESIGN: We recently reported the results of an association study between ASNase pathway genes and event-free survival (EFS) in childhood patients with ALL. The same polymorphisms were interrogated here in relation to...

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Identifiers

PMID: 24907114
DOI: 10.1158/1078-0432.CCR-14-0508
PMCID: PMC4258187

Genes

ASNS
EFS

Provenance

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