Article
DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.
Cancer discovery - 1 May 2016
Meyer Sara E, Qin Tingting, Muench David E, Masuda Kohei, Venkatasubramanian Meenakshi, Orr Emily, Suarez Lauren, Gore Steven D, Delwel Ruud, Paietta Elisabeth, Tallman Martin S, Fernandez Hugo, Melnick Ari, Le Beau Michelle M, Kogan Scott, Salomonis Nathan, Figueroa Maria E, Grimes H Leighton
Abstract excerpt
UNLABELLED: Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human AML. Co-occurring mutations in the de novo DNA methyltransferase DNMT3A and the FMS related tyrosine kinase 3 (FLT3) are common in CN-AML and confer a poorer prognosis. We demonstrate that mice with Flt3-internal tandem duplication (Flt3(ITD)) and inducible deletion of Dnmt3a spontaneously develop a rapidly lethal,...
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