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Article

Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association.

Leukemia - 1 Jun 2012

Renneville A, Boissel N, Nibourel O, Berthon C, Helevaut N, Gardin C, Cayuela J-M, Hayette S, Reman O, Contentin N, Bordessoule D, Pautas C, Botton S de, Revel T de, Terre C, Fenaux P, Thomas X, Castaigne S, Dombret H, Preudhomme C

Abstract excerpt

Recently, DNA methyltransferase 3A (DNMT3A) mutations have been identified in acute myeloid leukemia (AML), the highest frequency being found within cytogenetically normal (CN) AML. In this study, diagnostic samples from 123 adults younger than 60 years with primary CN-AML homogeneously treated in the Acute Leukemia French Association-9801 and -9802 trials were screened for mutations in DNMT3A-conserved domains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22289988
DOI: 10.1038/leu.2011.382

Genes

NPM1
EFS
FLT3
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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