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Article

Characteristics of DNMT3A mutations in acute myeloid leukemia

31 Mar 2020

Abstract excerpt

BackgroundDNMT3A mutations occur in approximately 20% of AML cases and are associated with changes in DNA methylation.CDKN2B plays an important role in the regulation of hematopoietic progenitor cells and DNMT3A mutation is associated with CDKN2B promoter methylation.We analyzed the characteristics of DNMT3A mutations including their clinical significance in AML and their influence on promoter methylation and...

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PMID: 32269971
DOI: 10.5045/br.2020.55.1.17

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