DNMT3A mutations in acute myeloid leukemia.

doi:10.1056/NEJMoa1005143

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Article

DNMT3A mutations in acute myeloid leukemia.

The New England journal of medicine - 16 Dec 2010

Ley Timothy J, Ding Li, Walter Matthew J, McLellan Michael D, Lamprecht Tamara, Larson David E, Kandoth Cyriac, Payton Jacqueline E, Baty Jack, Welch John, Harris Christopher C, Lichti Cheryl F, Townsend R Reid, Fulton Robert S, Dooling David J, Koboldt Daniel C, Schmidt Heather, Zhang Qunyuan, Osborne John R, Lin Ling, O'Laughlin Michelle, McMichael Joshua F, Delehaunty Kim D, McGrath Sean D, Fulton Lucinda A, Magrini Vincent J, Vickery Tammi L, Hundal Jasreet, Cook Lisa L, Conyers Joshua J, Swift Gary W, Reed Jerry P, Alldredge Patricia A, Wylie Todd, Walker Jason, Kalicki Joelle, Watson Mark A, Heath Sharon, Shannon William D, Varghese Nobish, Nagarajan Rakesh, Westervelt Peter, Tomasson Michael H, Link Daniel C, Graubert Timothy A, DiPersio John F, Mardis Elaine R, Wilson Richard K

Abstract excerpt

BACKGROUND: The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown. METHODS: Using massively parallel DNA sequencing, we identified a somatic mutation in DNMT3A, encoding a DNA methyltransferase, in the genome of cells from a pati...

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Identifiers

PMID: 21067377
DOI: 10.1056/NEJMoa1005143
PMCID: PMC3201818

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21067377-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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