Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased risk of strontium ranelate-related SJS/TEN is associated with HLA.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 1 Aug 2016

Lee H Y, Shen M X, Lim Y L, Tay Y K, Chan M M F, Pang S M, Xiao Z W, Ang S B, Ren E C

Abstract excerpt

UNLABELLED: Severe adverse drug reactions (ADR) of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) in some patients receiving strontium ranelate have been reported, but the risk factors are unclear. We show that HLA-A*33:03 and B*58:01 are significantly associated with patients who developed SJS/TEN; and provide the first evidence that genetic risk factors are involved in strontium...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Asian People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-A Antigens

Share to HLA-B Antigens

Share to Leukocytes, Mononuclear

Share to Osteoporosis

Share to Stevens-Johnson Syndrome

Share to Thiophenes

Source

Identifiers

PMID: 27003892
DOI: 10.1007/s00198-016-3568-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased risk of strontium ranelate-related SJS/TEN is associated with HLA.PMID 27003892Read ↗

The risk of anti-osteoporotic agent-induced severe cutaneous adverse drug reactions and their association with HLA.Semantic proximity Read ↗

Genetic Variants Associated with Non-Steroidal Anti-Inflammatory Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.Semantic proximity Read ↗

Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in EuropeSemantic proximity Read ↗

Genetics of Severe Cutaneous Adverse ReactionsSemantic proximity Read ↗

HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.Semantic proximity Read ↗

HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs.Semantic proximity Read ↗

Current Pharmacogenetic Perspective on Stevens-Johnson Syndrome and Toxic Epidermal NecrolysisSemantic proximity Read ↗

Risk factors of allopurinol-induced severe cutaneous adverse reactions in a Thai population.Semantic proximity Read ↗

Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population.Semantic proximity Read ↗

HLA-B*58:01 and Risk of Allopurinol-Induced Severe Cutaneous Adverse Reactions in the US.Semantic proximity Read ↗

Genetic predictors of Stevens-Johnson syndrome and toxic epidermal necrolysis induced by aromatic antiepileptic drugs among the Chinese Han population.Semantic proximity Read ↗

HLA-B*58:01 is an Incomplete Predictor of Allopurinol-Induced Severe Cutaneous Adverse ReactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.