Article
Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population.
Pharmacogenetics and genomics - 1 Sept 2009
Tassaneeyakul Wichittra, Jantararoungtong Thawinee, Chen Pei, Lin Pao-Yu, Tiamkao Somsak, Khunarkornsiri Usanee, Chucherd Pachadaporn, Konyoung Parinya, Vannaprasaht Suda, Choonhakarn Charoen, Pisuttimarn Pornrith, Sangviroon Alisara, Tassaneeyakul Wongwiwat
Abstract excerpt
OBJECTIVES: Allopurinol, a uric acid lowering drug commonly used for hyperuricemia and gouty arthritis, has been reported as a common cause of severe cutaneous adverse drug reactions (SCAR) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). A strong association between allopurinol-induced SCAR and HLA-B*5801 was observed in a Han Chinese population with high frequency of this allele,...
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