Article
Untangling the genetics of beta cell dysfunction and death in type 1 diabetes.
Molecular metabolism - 1 Aug 2024
Robertson Catherine C, Elgamal Ruth M, Henry-Kanarek Belle A, Arvan Peter, Chen Shuibing, Dhawan Sangeeta, Eizirik Decio L, Kaddis John S, Vahedi Golnaz, Parker Stephen C J, Gaulton Kyle J, Soleimanpour Scott A
Abstract excerpt
BACKGROUND: Type 1 diabetes (T1D) is a complex multi-system disease which arises from both environmental and genetic factors, resulting in the destruction of insulin-producing pancreatic beta cells. Over the past two decades, human genetic studies have provided new insight into the etiology of T1D, including an appreciation for the role of beta cells in their own demise. SCOPE OF REVIEW: Here, we outline models...
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