Article
De-coding genetic risk variants in type 1 diabetes.
Immunology and cell biology - 1 May 2021
Shapiro Melanie R, Thirawatananond Puchong, Peters Leeana, Sharp Robert C, Ogundare Similoluwa, Posgai Amanda L, Perry Daniel J, Brusko Todd M
Abstract excerpt
The conceptual basis for a genetic predisposition underlying the risk for developing type 1 diabetes (T1D) predates modern human molecular genetics. Over half of the genetic risk has been attributed to the human leukocyte antigen (HLA) class II gene region and to the insulin (INS) gene locus - both thought to confer direction of autoreactivity and tissue specificity. Notwithstanding, questions still remain...
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