Specific type 1 diabetes risk genes underpin age-at-diagnosis and indicate joint defects in immunity, beta-cell fragility and responses to viral infections in early-onset disease

Abstract excerpt

<h4>Objective</h4> Immunohistological analyses of pancreata from patients with type 1 diabetes suggest a stratification of islet pathology of both B and T lymphocyte islet inflammation common in children diagnosed at <7 years (<7 group), whereas B cells are rare in those diagnosed age ≥13 (≥13 group). Based on these observations, we sought to identify differences in genetic susceptibility between these age-at-dia...

Topics

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• Autoantibodies
• Autoimmunity
• Diabetes Mellitus, Type 1
• Disease Models, Animal
• Gastrointestinal Microbiome
• Gene-Environment Interaction
• HLA Antigens
• Insulin-Secreting Cells

Identifiers and source

Literature Corpus work

fccc596c-7f22-50cd-98bb-6ea48856b26d

DOI

10.1101/577304