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Article

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and <i>β</i> ‐cell apoptosis

1 Sept 2013

Abstract excerpt

Genome-wide association studies (GWAS) have identified more than 50 loci associated with genetic risk of type 1 diabetes (T1D). Several T1D candidate genes have been suggested or identified within these regions, but the molecular mechanisms by which they contribute to insulitis and β-cell destruction remain to be clarified. More than 60% of the T1D candidate genes are expressed in human pancreatic islets,...

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PMID: 24003923
DOI: 10.1111/dom.12162

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