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Article

Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression.

Immunity - 18 Feb 2020

Fasolino Maria, Goldman Naomi, Wang Wenliang, Cattau Benjamin, Zhou Yeqiao, Petrovic Jelena, Link Verena M, Cote Allison, Chandra Aditi, Silverman Michael, Joyce Eric F, Little Shawn C, Kaestner Klaus H, Naji Ali, Raj Arjun, Henao-Mejia Jorge, Faryabi Robert B, Vahedi Golnaz

Abstract excerpt

Genetics is a major determinant of susceptibility to autoimmune disorders. Here, we examined whether genome organization provides resilience or susceptibility to sequence variations, and how this would contribute to the molecular etiology of an autoimmune disease. We generated high-resolution maps of linear and 3D genome organization in thymocytes of NOD mice, a model of type 1 diabetes (T1D), and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32049053
DOI: 10.1016/j.immuni.2020.01.003
PMCID: PMC7152927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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