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Differential transcriptome analysis of diabetes-resistant and -sensitive mouse islets reveals significant overlap with human diabetes susceptibility genes.

Diabetes - 1 Dec 2014

Kluth Oliver, Matzke Daniela, Schulze Gunnar, Schwenk Robert W, Joost Hans-Georg, Schürmann Annette

Abstract excerpt

Type 2 diabetes in humans and in obese mice is polygenic. In recent genome-wide association studies, genetic markers explaining a small portion of the genetic contribution to the disease were discovered. However, functional evidence linking these genes with the pathogenesis of diabetes is scarce. We performed RNA sequencing-based transcriptomics of islets from two obese mouse strains, a diabetes-susceptible (NZO)...

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Identifiers

PMID: 25053586
DOI: 10.2337/db14-0425

Genes

GRB10
IGFBP2
PRC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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