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Article

Pancreatic Beta Cell Survival and Signaling Pathways: Effects of Type 1 Diabetes-Associated Genetic Variants.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Santin Izortze, Dos Santos Reinaldo S, Eizirik Decio L

Abstract excerpt

Type 1 diabetes (T1D) is a complex autoimmune disease in which pancreatic beta cells are specifically destroyed by the immune system. The disease has an important genetic component and more than 50 loci across the genome have been associated with risk of developing T1D. The molecular mechanisms by which these putative T1D candidate genes modulate disease risk, however, remain poorly characterized and little is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26936771
DOI: 10.1007/7651_2015_291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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