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Article

Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults.

Brain structure & function - 1 Aug 2017

Shen Junlin, Qin Wen, Xu Qiang, Xu Lixue, Xu Jiayuan, Zhang Peng, Liu Huaigui, Liu Bing, Jiang Tianzi, Yu Chunshui

Abstract excerpt

Apolipoprotein E (APOE) and sortilin-related receptor (SORL1) genes act on the same metabolic pathway and have been associated with Alzheimer's disease (AD) characterized by hippocampal impairment. Although the effects of APOE on hippocampal resting-state functional connectivity (rsFC) have been reported, the main effects of SORL1 and SORL1 × APOE interactions on hippocampal rsFC in healthy subjects remain...

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Identifiers

PMID: 28229235
DOI: 10.1007/s00429-017-1377-3
PMCID: PMC5541082

Genes

APOE
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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