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Article

SORL1 rs1699102 polymorphism modulates age-related cognitive decline and gray matter volume reduction in non-demented individuals.

European journal of neurology - 1 Jan 2017

Li He, Lv Chenlong, Yang Caishui, Wei Dongfeng, Chen Kewei, Li Shaowu, Zhang Zhanjun

Abstract excerpt

BACKGROUND AND PURPOSE: SORL1 rs1699102 is associated with the risk of late-onset Alzheimer's disease. However, the effects of this single nucleotide polymorphism on cognition and brain structure during normal aging are unclear. This study aimed to examine the effects of the rs1699102 polymorphism on age-related cognitive decline and cortical gray matter reduction in the Chinese Han population. METHODS: A total...

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Identifiers

PMID: 27779372
DOI: 10.1111/ene.13182
PMCID: PMC5177470

Genes

SORL1

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