Article
Sex moderates the effects of the Sorl1 gene rs2070045 polymorphism on cognitive impairment and disruption of the cingulum integrity in healthy elderly.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2015
Liang Ying, Li He, Lv Chenlong, Shu Ni, Chen Kewei, Li Xin, Zhang Junying, Hu Liangping, Zhang Zhanjun
Abstract excerpt
The SORL1 rs2070045 polymorphism was reported to be associated with SorLA expression in the brain and the risk of late-onset Alzheimer's disease (AD). However, the influence of this polymorphism on cognitive functioning is likely to be moderated by sex. This study aimed to examine the sex moderation on the effects of rs2070045 on neuropsychological performance and the cingulum integrity in Chinese Han population....
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