Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A platform for interrogating cancer-associated p53 alleles.

Oncogene - 12 Jan 2017

D'Brot A, Kurtz P, Regan E, Jakubowski B, Abrams J M

Abstract excerpt

p53 is the most frequently mutated gene in human cancer. Compelling evidence argues that full transformation involves loss of growth suppression encoded by wild-type p53 together with poorly understood oncogenic activity encoded by missense mutations. Furthermore, distinguishing disease alleles from natural polymorphisms is an important clinical challenge. To interrogate the genetic activity of human p53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Animals, Genetically Modified
Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Drosophila melanogaster

Share to Models, Animal

Share to Neoplasms

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 26996664
DOI: 10.1038/onc.2016.48
PMCID: PMC5031501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A platform for interrogating cancer-associated p53 alleles.PMID 26996664Read ↗

High throughput evaluation of genetic variants with prime editing sensor librariesSemantic proximity Read ↗

Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypesSemantic proximity Read ↗

A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation.Semantic proximity Read ↗

Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers.Semantic proximity Read ↗

Exploring mutational signatures in human cancers using human cell line modelsSemantic proximity Read ↗

Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses.Semantic proximity Read ↗

A simple p53 functional assay for screening cell lines, blood, and tumors.Semantic proximity Read ↗

Assessing p53 in clinical contexts: unlearned lessons and new perspectives.Semantic proximity Read ↗

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.Semantic proximity Read ↗

Sentinel interaction mapping - a generic approach for the functional analysis of human disease gene variants using yeast.Semantic proximity Read ↗

Mouse models with modified p53 sequences to study cancer and ageing.Semantic proximity Read ↗

p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.