Article
Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.
Oncogene - 15 Apr 1999
Smith P D, Crossland S, Parker G, Osin P, Brooks L, Waller J, Philp E, Crompton M R, Gusterson B A, Allday M J, Crook T
Abstract excerpt
Inheritance of germ-line mutant alleles of BRCA1 and BRCA2 confers a markedly increased risk of breast cancer and we have previously reported a higher incidence of p53 mutations in these tumours than in grade matched sporadic tumours. We have now characterized these p53 mutants. The results of these studies identify a novel class of p53 mutants previously undescribed in human cancer yet with multiple occurrences...
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