Article
Assessing p53 in clinical contexts: unlearned lessons and new perspectives.
The Journal of pathology - 1 Jan 2006
Hall Peter A, McCluggage W Glenn
Abstract excerpt
There is compelling evidence for the central role of the p53 pathway in human neoplasia but, despite an enormous literature, the clinical utility of assessing this pathway remains ambiguous. Even simple questions about the assessment of p53 status in clinical samples remain unanswered and the literature is confusing and often contradictory. The p53 pathway is certainly complicated and the biochemical mechanisms...
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