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Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes

31 Aug 2021

Abstract excerpt

p53 is mutated in over half of human cancers. In addition to losing wild-type (WT) tumor-suppressive function, mutant p53 proteins are proposed to acquire gain-of-function (GOF) activity, leading to novel oncogenic phenotypes. To study mutant p53 GOF mechanisms and phenotypes, we genetically engineered non-transformed and tumor-derived WT p53 cell line models to express endogenous missense mutant p53 (R175H and...

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PMID: 34465782
DOI: 10.1038/s41467-021-25359-z

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