Article
p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors.
Oncogene - 23 Apr 1998
Epstein C B, Attiyeh E F, Hobson D A, Silver A L, Broach J R, Levine A J
Abstract excerpt
p53 is a transcriptional activator that plays a key role in the integration of signals inducing cell division arrest and programmed cell death. Moreover, p53 is a tumor suppressor gene, mutations of which are the most commonly detected mutations in diverse malignancies. In order to better underst...
Topics
- Alleles
- Creatine Kinase
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enhancer Elements, Genetic
- Humans
- Mutagenesis
- Nuclear Proteins
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- Transcription Factors
- Transcriptional Activation
- Tumor Suppressor Protein p53
- Yeasts