Article
Maternal trans-general analysis of the human mitochondrial DNA pattern.
Biochemical and biophysical research communications - 4 Nov 2017
Han Xiao, Zhao Zitong, Zhang Minjie, Li Guochao, Yang Caiyun, Du Fengxia, Wang Junyun, Zhang Yan, Wang Yuanyuan, Jia Yongsheng, Li Binghui, Sun Yingli
Abstract excerpt
There is an intimate connection between mitochondrial DNA (mtDNA) methylation and some diseases, such as cancer. MtDNA is almost strictly maternally inherited. However, whether the aberrant mtDNA methylation involved in breast cancer progression and whether mtDNA methylation can be transmitted through maternal line are poorly understood. Here we applied bisulfite sequencing to global mitochondrial DNA and whole...
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