Article

Epigenome-wide Association Analysis of Mitochondrial Heteroplasmy Provides Insight into Molecular Mechanisms of Disease

2024-12-08

Abstract excerpt

<h4>ABSTRACT</h4> The relationship between mitochondrial DNA (mtDNA) heteroplasmy and nuclear DNA (nDNA) methylation (CpGs) remains to be studied. We conducted an epigenome-wide association analysis of heteroplasmy burden scores across 10,986 participants (mean age 77, 63% women, and 54% non-White races/ethnicities) from seven population-based observational cohorts. We identified 412 CpGs (FDR p < 0.05) associated...

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Literature Corpus work: 4ef1abd6-1c6b-5f2a-a075-c6c71dedfd61
DOI: 10.1101/2024.12.05.24318557

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