Article
The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.
Fungal genetics and biology : FG & B - 1 Jun 2016
Wu Shiao-Yii, Kuan Vivian Jen-Wei, Tzeng Yao-Wei, Schuyler Scott C, Juang Yue-Li
Abstract excerpt
In Saccharomyces cerevisiae, the S-phase cyclin Clb6 is expressed shortly before the G1/S transition. It has been shown that in S phase the SCF(Cdc4) ubiquitin ligase controls Clb6 proteolysis, which requires cyclin-dependent kinases activity. A Clb6-3A mutant, bearing non-phosphorylatable mutations at S6A, T39A, and S147A, was observed to be hyperstabilized in S-phase but was unstable in mitosis. In this study,...
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