Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.

Molecular and cellular biology - 1 Mar 2006

Jackson Leisa P, Reed Steven I, Haase Steven B

Abstract excerpt

The yeast S-phase cyclins Clb5 and Clb6 are closely related proteins that are synthesized late in G1. Although often grouped together with respect to function, Clb5 and Clb6 exhibit differences in their ability to promote S-phase progression. DNA replication is significantly slowed in clb5Delta mutants but not in clb6Delta mutants. We have examined the basis for the differential functions of Clb5 and Clb6 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to CDC28 Protein Kinase, S cerevisiae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin B

Share to Cyclin-Dependent Kinases

Share to F-Box Proteins

Share to S Phase

Share to Ubiquitin-Conjugating Enzymes

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 16508019
DOI: 10.1128/MCB.26.6.2456-2466.2006
PMCID: PMC1430301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.PMID 16508019Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

Negative regulation of G1 and G2 by S-phase cyclins of Saccharomyces cerevisiae.Semantic proximity Read ↗

Among B-type cyclins only CLB5 and CLB6 promote premeiotic S phase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.Semantic proximity Read ↗

The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing.Semantic proximity Read ↗

G2 cyclins are required for the degradation of G1 cyclins in yeast.Semantic proximity Read ↗

CLB5 and CLB6 are required for premeiotic DNA replication and activation of the meiotic S/M checkpoint.Semantic proximity Read ↗

Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase.Semantic proximity Read ↗

CLB5: a novel B cyclin from budding yeast with a role in S phase.Semantic proximity Read ↗

DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae.Semantic proximity Read ↗

Novel functional dissection of the localization-specific roles of budding yeast polo kinase Cdc5p.Semantic proximity Read ↗

Diminished S-phase cyclin-dependent kinase function elicits vital Rad53-dependent checkpoint responses in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.