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Article

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

Science (New York, N.Y.) - 17 Oct 1997

Visintin R, Prinz S, Amon A

Abstract excerpt

Proteolysis mediated by the anaphase-promoting complex (APC) triggers chromosome segregation and exit from mitosis, yet its regulation is poorly understood. The conserved Cdc20 and Cdh1 proteins were identified as limiting, substrate-specific activators of APC-dependent proteolysis. CDC20 was required for the degradation of the APC substrate Pds1 but not for that of other APC substrates, such as Clb2 and Ase1....

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Source

Identifiers

PMID: 9334304
DOI: 10.1126/science.278.5337.460

Genes

APC
CDC20
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.PMID 9334304Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.Semantic proximity Read ↗

Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex.Semantic proximity Read ↗

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.Semantic proximity Read ↗

Mitotic regulation of the APC activator proteins CDC20 and CDH1.Semantic proximity Read ↗

The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cellsSemantic proximity Read ↗

APC/C(Cdh1)-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycle.Semantic proximity Read ↗

Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.Semantic proximity Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.Semantic proximity Read ↗

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