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Article

Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex.

Molecular and cellular biology - 1 Jul 2000

Burton J L, Solomon M J

Abstract excerpt

Ubiquitination and subsequent degradation of critical cell cycle regulators is a key mechanism exploited by the cell to ensure an irreversible progression of cell cycle events. The anaphase-promoting complex (APC) is a ubiquitin ligase that targets proteins for degradation by the 26S proteasome. Here we identify the Hsl1p protein kinase as an APC substrate that interacts with Cdc20p and Cdh1p, proteins that...

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Share to Anaphase-Promoting Complex-Cyclosome
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Share to Cyclin-Dependent Kinases

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Source

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Identifiers

PMID: 10848588
DOI: 10.1128/MCB.20.13.4614-4625.2000
PMCID: PMC85864

Genes

APC
CDC23
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex.PMID 10848588Read ↗

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.Semantic proximity Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.Semantic proximity Read ↗

Clb2 and the APC/C(Cdh1) regulate Swe1 stability.Semantic proximity Read ↗

Determinants of Swe1p degradation in Saccharomyces cerevisiae.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.Semantic proximity Read ↗

The role of Cdh1p in maintaining genomic stability in budding yeast.Semantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.Semantic proximity Read ↗

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