Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex.

Molecular and cellular biology - 1 Jul 2000

Burton J L, Solomon M J

Abstract excerpt

Ubiquitination and subsequent degradation of critical cell cycle regulators is a key mechanism exploited by the cell to ensure an irreversible progression of cell cycle events. The anaphase-promoting complex (APC) is a ubiquitin ligase that targets proteins for degradation by the 26S proteasome....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Cdc20 Proteins
Share to Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligases

Share to Precipitin Tests

Share to Two-Hybrid System Techniques

Share to Ubiquitin-Protein Ligase Complexes

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 10848588
DOI: 10.1128/MCB.20.13.4614-4625.2000
PMCID: PMC85864

Genes

APC
CDC23
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10848588-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hsl1p, a Swe1p inhibitor, is degraded via the anaphase-promoting complex.PMID 10848588Read ↗

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.Semantic proximity Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.Semantic proximity Read ↗

Clb2 and the APC/C(Cdh1) regulate Swe1 stability.Semantic proximity Read ↗

Determinants of Swe1p degradation in Saccharomyces cerevisiae.Semantic proximity Read ↗

RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.Semantic proximity Read ↗

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.Semantic proximity Read ↗

The role of Cdh1p in maintaining genomic stability in budding yeast.Semantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.