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Article

Clb2 and the APC/C(Cdh1) regulate Swe1 stability.

Cell cycle (Georgetown, Tex.) - 1 Aug 2010

Simpson-Lavy Kobi J, Brandeis Michael

Abstract excerpt

Swe1/Wee1 regulates mitotic entry by inhibiting Clb2-Cdk1 and its accumulation is involved in stress induced G(2) arrest. The APC/C(Cdh1) substrates Cdc5, Clb2 and Hsl1 regulate Swe1 degradation. We observed that clb2Deltacdh1Delta double mutant S. cerevisiae does not express any detectable levels of Swe1, presumably due to its constitutive degradation. This effect of Cdh1 inactivation is due to stabilization of...

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Share to Anaphase-Promoting Complex-Cyclosome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20714223
DOI: 10.4161/cc..9.115.12457

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Clb2 and the APC/C(Cdh1) regulate Swe1 stability.PMID 20714223Read ↗

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Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.Semantic proximity Read ↗

The role of Cdh1p in maintaining genomic stability in budding yeast.Semantic proximity Read ↗

Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation.Semantic proximity Read ↗

Role of Ndt80, Sum1, and Swe1 as targets of the meiotic recombination checkpoint that control exit from pachytene and spore formation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis.Semantic proximity Read ↗

Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.Semantic proximity Read ↗

Cytoplasmic Clb2 is required for timely inactivation of the mitotic inhibitor Swe1 and normal bud morphogenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

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