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Article

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.

Nature - 11 Nov 1999

Shirayama M, Tóth A, Gálová M, Nasmyth K

Abstract excerpt

Ubiquitin-mediated proteolysis due to the anaphase-promoting complex/cyclosome (APC/C) is essential for separation of sister chromatids, requiring degradation of the anaphase inhibitor Pds1, and for exit from mitosis, requiring inactivation of cyclin B Cdk1 kinases. Exit from mitosis in yeast involves accumulation of the cyclin kinase inhibitor Sic1 as well as cyclin proteolysis mediated by APC/C bound by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10647015
DOI: 10.1038/46080

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.PMID 10647015Read ↗

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus.Semantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus.Semantic proximity Read ↗

Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p.Semantic proximity Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.Semantic proximity Read ↗

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.Semantic proximity Read ↗

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae.Semantic proximity Read ↗

The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase.Semantic proximity Read ↗

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage.Semantic proximity Read ↗

Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.Semantic proximity Read ↗

Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase.Semantic proximity Read ↗

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