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Article

A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Oct 1998

Jaspersen S L, Charles J F, Tinker-Kulberg R L, Morgan D O

Abstract excerpt

Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinase-cyclin complexes, primarily by ubiquitin-dependent cyclin proteolysis. Cyclin destruction is regulated by a ubiquitin ligase known as the anaphase-promoting complex (APC). In the budding yeast Saccharomyces cerevisiae, members of a large class of late mitotic mutants, including cdc15, cdc5, cdc14, dbf2, and tem1, arrest in anaphase...

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Identifiers

PMID: 9763445
DOI: 10.1091/mbc.9.10.2803
PMCID: PMC25555

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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