Article
A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae.
Molecular biology of the cell - 1 Oct 1998
Jaspersen S L, Charles J F, Tinker-Kulberg R L, Morgan D O
Abstract excerpt
Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinase-cyclin complexes, primarily by ubiquitin-dependent cyclin proteolysis. Cyclin destruction is regulated by a ubiquitin ligase known as the anaphase-promoting complex (APC). In the budding yeast Saccharomyces cerevisiae,...
Topics
- Anaphase-Promoting Complex-Cyclosome
- Cell Cycle
- Cyclin B
- Cyclin-Dependent Kinase Inhibitor Proteins
- Cyclin-Dependent Kinases
- Cyclins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genotype
- Intracellular Signaling Peptides and Proteins
- Ligases
- Mitosis
- Models, Biological
- Phenotype
- Protein Serine-Threonine Kinases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Suppression, Genetic