Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins.

doi:10.1038/373078a0

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Article

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins.

Nature - 5 Jan 1995

Seufert W, Futcher B, Jentsch S

Abstract excerpt

Cell cycle progression in eukaryotes is controlled by the p34cdc2/CDC28 protein kinase and its short-lived, phase-specific regulatory subunits called cyclins. In Xenopus oocytes, degradation of M-phase (B-type) cyclins is required for exit from mitosis and is mediated by the ubiquitin-dependent p...

Topics

Amino Acid Sequence
Animals
Cloning, Molecular
Cyclin B
Cyclins
DNA, Fungal
Fungal Proteins
Ligases
Mitosis
Molecular Sequence Data
Mutation
Oocytes
S Phase
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Ubiquitin-Conjugating Enzymes
Xenopus
Ubiquitin-Conjugating Enzyme UBC9

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