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Article

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins.

Nature - 5 Jan 1995

Seufert W, Futcher B, Jentsch S

Abstract excerpt

Cell cycle progression in eukaryotes is controlled by the p34cdc2/CDC28 protein kinase and its short-lived, phase-specific regulatory subunits called cyclins. In Xenopus oocytes, degradation of M-phase (B-type) cyclins is required for exit from mitosis and is mediated by the ubiquitin-dependent proteolytic system. Here we show that B-type-cyclin degradation in yeast involves an essential nuclear...

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PMID: 7800043
DOI: 10.1038/373078a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins.PMID 7800043Read ↗

G2 cyclins are required for the degradation of G1 cyclins in yeast.Semantic proximity Read ↗

Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets.Semantic proximity Read ↗

DNA damage inhibits proteolysis of the B-type cyclin Clb5 in S. cerevisiae.Semantic proximity Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin.Semantic proximity Read ↗

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

Compartmentalization of the functions and regulation of the mitotic cyclin Clb2 in S. cerevisiae.Semantic proximity Read ↗

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.Semantic proximity Read ↗

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.Semantic proximity Read ↗

The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.Semantic proximity Read ↗

The destruction box of the cyclin Clb2 binds the anaphase-promoting complex/cyclosome subunit Cdc23.Semantic proximity Read ↗

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