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Article

The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase.

Journal of cell science - 1 Jul 1997

Irniger S, Nasmyth K

Abstract excerpt

Inactivation of B-type cyclin dependent kinases due to ubiquitin-mediated cyclin proteolysis is necessary for the exit from mitosis. In Saccharomyces cerevisiae, proteolysis is initiated at the onset of anaphase and remains active until Cln1 and Cln2 cyclins appear in late G1 of the subsequent ce...

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Source

Identifiers

PMID: 9224769
DOI: 10.1242/jcs.110.13.1523

Genes

APC
TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9224769-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase.PMID 9224769Read ↗

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).Semantic proximity Read ↗

The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.Semantic proximity Read ↗

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5.Semantic proximity Read ↗

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae.Semantic proximity Read ↗

A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae.Semantic proximity Read ↗

G2 cyclins are required for the degradation of G1 cyclins in yeast.Semantic proximity Read ↗

Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery.Semantic proximity Read ↗

Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase.Semantic proximity Read ↗

The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast.Semantic proximity Read ↗

Cdc48p is required for the cell cycle commitment point at Start via degradation of the G1-CDK inhibitor Far1p.Semantic proximity Read ↗

Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex.Semantic proximity Read ↗

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