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Article

Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase.

Molecular and cellular biology - 1 Aug 2001

Yeong F M, Lim H H, Wang Y, Surana U

Abstract excerpt

Periodic accumulation and destruction of mitotic cyclins are important for the initiation and termination of M phase. It is known that both APC(Cdc20) and APC(Hct1) collaborate to destroy mitotic cyclins during M phase. Here we show that this relationship between anaphase-promoting complex (APC) and Clb proteins is reversed in S phase such that the early Clb kinases (Clb3, Clb4, and Clb5 kinases) inactivate...

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Identifiers

PMID: 11438663
DOI: 10.1128/MCB.21.15.5071-5081.2001
PMCID: PMC87233

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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