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Article

Studies of mice with cyclic AMP-dependent protein kinase (PKA) defects reveal the critical role of PKA's catalytic subunits in anxiety.

Behavioural brain research - 1 Jul 2016

Briassoulis George, Keil Margaret F, Naved Bilal, Liu Sophie, Starost Matthew F, Nesterova Maria, Gokarn Nirmal, Batistatos Anna, Wu T John, Stratakis Constantine A

Abstract excerpt

Cyclic adenosine mono-phosphate-dependent protein kinase (PKA) is critically involved in the regulation of behavioral responses. Previous studies showed that PKA's main regulatory subunit, R1α, is involved in anxiety-like behaviors. The purpose of this study was to determine how the catalytic subunit, Cα, might affect R1α's function and determine its effects on anxiety-related behaviors. The marble bury (MB) and...

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Identifiers

PMID: 26992826
DOI: 10.1016/j.bbr.2016.03.001
PMCID: PMC4853257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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