Article
Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010
Kelly Michele P, Logue Sheree F, Brennan Julie, Day Jonathon P, Lakkaraju Subha, Jiang Lixin, Zhong Xiaotian, Tam May, Sukoff Rizzo Stacey J, Platt Brian J, Dwyer Jason M, Neal Sarah, Pulito Virginia L, Agostino Michael J, Grauer Steven M, Navarra Rachel L, Kelley Cody, Comery Thomas A, Murrills Richard J, Houslay Miles D, Brandon Nicholas J
Abstract excerpt
Phosphodiesterase 11A (PDE11A) is the most recently identified family of phosphodiesterases (PDEs), the only known enzymes to break down cyclic nucleotides. The tissue expression profile of this dual specificity PDE is controversial, and little is understood of its biological function, particularly in the brain. We seek here to determine if PDE11A is expressed in the brain and to understand its function, using...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Animals
- Behavior, Animal
- Female
- Gene Expression Regulation, Enzymologic
- Glutamine
- Hippocampus
- Male