Article
Threat bias in mice with inactivating mutations of Prkar1a.
Neuroscience - 25 Jun 2013
Keil M F, Briassoulis G, Nesterova M, Miraftab N, Gokarn N, Wu T J, Stratakis C A
Abstract excerpt
Anxiety disorders are associated with abnormalities in the neural processing of threat-related stimuli. However, the neurobiological mechanisms underlying threat bias in anxiety are not well understood. We recently reported that a Prkar1a heterozygote (Prkar1a(+/-)) mouse with haploinsufficiency for the main regulatory subunit (R1α) of protein kinase A (PKA) exhibits an anxiety-like phenotype associated with...
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