Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.

Scientific reports - 21 Jan 2021

Hoang Trung Hieu, Yoshihara Toru, Nakao Akito, Hayashida Katsumi, Hirata Yoshiki, Shirasuna Koumei, Kuwamura Mitsuru, Nakagawa Yuki, Kaneko Takehito, Mori Yasuo, Asano Masahide, Kuramoto Takashi

Abstract excerpt

The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear conditioning tests. Here, we combined genetic, electrophysiological, and behavioral approaches to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hippocampus

Share to Memory

Share to Memory Disorders

Share to Neuronal Plasticity

Share to Tremor

Source

Open in PubMed Open full text

Identifiers

PMID: 33479380
DOI: 10.1038/s41598-021-81515-x
PMCID: PMC7820254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.PMID 33479380Read ↗

Studies of mice with cyclic AMP-dependent protein kinase (PKA) defects reveal the critical role of PKA's catalytic subunits in anxiety.Semantic proximity Read ↗

Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.Semantic proximity Read ↗

FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.Semantic proximity Read ↗

A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.Semantic proximity Read ↗

A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.Semantic proximity Read ↗

Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.Semantic proximity Read ↗

Bidirectional regulation of hippocampal long-term synaptic plasticity and its influence on opposing forms of memory.Semantic proximity Read ↗

Phenotyping of FGF12AV52H mutation in mouse implies a complex FGF12 network.Semantic proximity Read ↗

Selective expression of a dominant-negative type Iα PKA regulatory subunit in striatal medium spiny neurons impairs gene expression and leads to reduced feeding and locomotor activity.Semantic proximity Read ↗

Protein Kinase A in neurological disordersSemantic proximity Read ↗

Anxiety phenotype in mice that overexpress protein kinase A.Semantic proximity Read ↗

Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.