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Article

Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II.

Science (New York, N.Y.) - 14 Oct 1994

Chen C, Rainnie D G, Greene R W, Tonegawa S

Abstract excerpt

Mice deficient for the gene encoding alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion. The heterozygous mouse exhibited a well-circumscribed syndrome of behavioral abnormalities, consisting primarily of a decreased fear response and an increase in defensive aggression, in the absence of...

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Identifiers

PMID: 7939668
DOI: 10.1126/science.7939668

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