Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II.

doi:10.1126/science.7939668

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Article

Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II.

Science (New York, N.Y.) - 14 Oct 1994

Chen C, Rainnie D G, Greene R W, Tonegawa S

Abstract excerpt

Mice deficient for the gene encoding alpha-calcium-calmodulin-dependent kinase II (alpha-CaMKII knockout mice) provide a promising tool to link behavioral and cellular abnormalities with a specific molecular lesion. The heterozygous mouse exhibited a well-circumscribed syndrome of behavioral abno...

Topics

Aggression
Animals
Behavior, Animal
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Fear
Fluoxetine
Gene Dosage
Heterozygote
Homozygote
In Vitro Techniques
Membrane Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Mutation

Neurons

Patch-Clamp Techniques

Raphe Nuclei

Source

Open in PubMed

Identifiers

PMID: 7939668
DOI: 10.1126/science.7939668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7939668-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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