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Article

Anxiety phenotype in mice that overexpress protein kinase A.

Psychoneuroendocrinology - 1 Jun 2012

Keil Margaret F, Briassoulis George, Gokarn Nirmal, Nesterova Maria, Wu T John, Stratakis Constantine A

Abstract excerpt

The role of cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signaling in the molecular pathways involved in fear and memory is well established. Prior studies in our lab reported that transgenic mice with an inactivating mutation in Prkar1a gene (codes for the 1-alpha regulatory subunit (R1α) of PKA) exhibited behavioral abnormalities including anxiety and depression. In the present study, we examined...

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Identifiers

PMID: 22024111
DOI: 10.1016/j.psyneuen.2011.09.016
PMCID: PMC3320692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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