Article

Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing’s syndrome

2021-10-19

Abstract excerpt

Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone disorder adrenal Cushing’s syndrome. Here we define mechanisms of action for the PKAc-L205R and W196R variants. Both Cushing’s mutants are excluded from A kinase anchoring protein (AKAP) signaling islands and consequently diffuse throughout the cell. Kinase-dead experiments show that PKA activity is required for cortisol hyperse...

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Literature Corpus work: d9abd1b7-b001-5fc4-b401-b6880b2fcc4f
DOI: 10.1101/2021.10.18.464848

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