Article
Anxiety-like behavior and other consequences of early life stress in mice with increased protein kinase A activity.
Behavioural brain research - 1 Aug 2018
Ugolini Maddalena, Keil Margaret F, Paradiso Enrica, Wu John, Stratakis Constantine A
Abstract excerpt
Anxiety disorders are associated with abnormalities in fear-learning and bias to threat; early life experiences are influential to the development of an anxiety-like phenotype in adulthood. We recently reported that adult mice (Prkar1a+/-) with haploinsufficiency for the main regulatory subunit of the protein kinase A (PKA) exhibit an anxiety-like phenotype associated with increased PKA activity in the amygdala....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.