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Article

Cell-type specific expression of a dominant negative PKA mutation in mice.

PloS one - 12 Apr 2011

Willis Brandon S, Niswender Colleen M, Su Thomas, Amieux Paul S, McKnight G Stanley

Abstract excerpt

We employed the Cre recombinase/loxP system to create a mouse line in which PKA activity can be inhibited in any cell-type that expresses Cre recombinase. The mouse line carries a mutant Prkar1a allele encoding a glycine to aspartate substitution at position 324 in the carboxy-terminal cAMP-binding domain (site B). This mutation produces a dominant negative RIα regulatory subunit (RIαB) and leads to inhibition of...

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Identifiers

PMID: 21533282
DOI: 10.1371/journal.pone.0018772
PMCID: PMC3075275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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