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Article

Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases.

International journal of cancer - 1 Aug 2016

Løes Inger Marie, Immervoll Heike, Sorbye Halfdan, Angelsen Jon-Helge, Horn Arild, Knappskog Stian, Lønning Per Eystein

Abstract excerpt

We determined prognostic impact of KRAS, BRAF, PIK3CA and TP53 mutation status and mutation heterogeneity among 164 colorectal cancer (CRC) patients undergoing liver resections for metastatic disease. Mutation status was determined by Sanger sequencing of a total of 422 metastatic deposits. In univariate analysis, KRAS (33.5%), BRAF (6.1%) and PIK3CA (13.4%) mutations each predicted reduced median time to relapse...

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Source

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Identifiers

PMID: 26991344
DOI: 10.1002/ijc.30089
PMCID: PMC5071774

Genes

BRAF
KRAS
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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