Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.

doi:10.1158/1078-0432.CCR-17-0306

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Article

Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2017

Joung Je-Gun, Oh Bo Young, Hong Hye Kyung, Al-Khalidi Hisham, Al-Alem Faisal, Lee Hae-Ock, Bae Joon Seol, Kim Jinho, Cha Hong-Ui, Alotaibi Maram, Cho Yong Beom, Hassanain Mazen, Park Woong-Yang, Lee Woo Yong

Abstract excerpt

Purpose: Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In this study, we compared mutations in paired primary and metastatic colorectal cancer tumor samples to determine whether tumor heterogeneity can predict tumor metastasis.Experimental Design: Somatic variations in 46 pairs of matched primary-liver metastatic tumors and 42...

Topics

Adenomatous Polyposis Coli Protein
Aged
Class I Phosphatidylinositol 3-Kinases
Colorectal Neoplasms
Female
Gene Frequency
Genetic Heterogeneity
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Proto-Oncogene Proteins p21(ras)

Receptor, Notch1

Tumor Suppressor Protein p53

Exome Sequencing

Source

Open in PubMed

Identifiers

PMID: 28939741
DOI: 10.1158/1078-0432.CCR-17-0306

Genes

APC
KRAS
NOTCH1

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