Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of intermetastatic heterogeneity for pathological response and genetic mutations within colorectal liver metastases following preoperative chemotherapy.

Oncotarget - 19 Apr 2016

Sebagh Mylène, Allard Marc-Antoine, Bosselut Nelly, Dao Myriam, Vibert Eric, Lewin Maïté, Lemoine Antoinette, Cherqui Daniel, Adam René, Sa Cunha Antonio

Abstract excerpt

BACKGROUND: In patients receiving preoperative chemotherapy, colorectal liver metastases (CLM) are expected to demonstrate a similar behaviour because of similar organ microenvironment and tumour cell chemosensitivity. We focused on the occurrence of pathological and genetic heterogeneity within CLM. METHODS: Patients resected for multiple CLM between 2004 and 2011 after > three cycles of chemotherapy were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to GTP Phosphohydrolases

Share to Liver Neoplasms

Share to Multivariate Analysis

Share to Proto-Oncogene Proteins p21(ras)

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 26943031
DOI: 10.18632/oncotarget.7809
PMCID: PMC5008308

Genes

BRAF
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of intermetastatic heterogeneity for pathological response and genetic mutations within colorectal liver metastases following preoperative chemotherapy.PMID 26943031Read ↗

High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases.Semantic proximity Read ↗

Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases.Semantic proximity Read ↗

Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver ResectionSemantic proximity Read ↗

Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer.Semantic proximity Read ↗

Genomic and Prognostic Heterogeneity Among RAS/BRAFV600E/TP53 Co-Mutated Resectable Colorectal Liver MetastasesSemantic proximity Read ↗

Tumor Heterogeneity in Primary Colorectal Cancer and Corresponding Metastases. Does the Apple Fall Far From the Tree?Semantic proximity Read ↗

Heterogeneity in primary colorectal cancer and its corresponding metastases: a potential reason of EGFR-targeted therapy failure?Semantic proximity Read ↗

Intratumoral morphological heterogeneity can be an indicator of genetic heterogeneity in colorectal cancer.Semantic proximity Read ↗

Tumor Heterogeneity in Colorectal Cancer: What Do We Know So Far?Semantic proximity Read ↗

The significance of intertumor and intratumor heterogeneity in liver cancer.Semantic proximity Read ↗

Proof-of-concept pilot study on comprehensive spatiotemporal intra-patient heterogeneity for colorectal cancer with liver metastasisSemantic proximity Read ↗

Genomic and prognostic heterogeneity among RAS/BRAFV600E /TP53 co-mutated resectable colorectal liver metastases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.