Clinical impact of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status on recurrence patterns and the efficacy of local therapy after hepatectomy for colorectal liver metastases.

doi:10.1007/s00595-026-03377-y

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Article

Clinical impact of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status on recurrence patterns and the efficacy of local therapy after hepatectomy for colorectal liver metastases.

Surgery today - 1 Oct 2026

Kanemitsu Kosuke, Hayashi Hiromitsu, Tagayasu Yoshiyuki, Tanizaki Takumi, Adachi Yuki, Ofuchi Takashi, Tajiri Takuya, Kitano Yuki, Okabe Hirohisa, Iwatsuki Masaaki

Abstract excerpt

PURPOSES: The Kirsten rat sarcoma viral oncogene homolog (KRAS) is defined as frequently mutated oncogenes in colorectal cancer. We aimed to clarify the clinical impact of KRAS mutation status on recurrence patterns, the surgical management of recurrent lesions, and prognostic outcomes after curative hepatectomy for colorectal liver metastases (CRLM). METHODS: The subjects of this retrospective study were 190...

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Topics

Humans
Liver Neoplasms
Colorectal Neoplasms
Proto-Oncogene Proteins p21(ras)
Hepatectomy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Neoplasm Recurrence, Local

Retrospective Studies

Female

Male

Prognosis

Treatment Outcome

Middle Aged

Aged

Survival Rate

Source

Open in PubMed

Identifiers

PMID: 42384210
DOI: 10.1007/s00595-026-03377-y

Genes

KRAS

Provenance

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Clinical impact of Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation status on recurrence patterns and the efficacy of local therapy after hepatectomy for colorectal liver metastases.PMID 42384210Read ↗

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