Article
High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases.
Clinical colorectal cancer - 1 Mar 2020
Brunsell Tuva Høst, Sveen Anita, Bjørnbeth Bjørn Atle, Røsok Bård I, Danielsen Stine Aske, Brudvik Kristoffer Watten, Berg Kaja C G, Johannessen Bjarne, Cengija Vanja, Abildgaard Andreas, Guren Marianne Grønlie, Nesbakken Arild, Lothe Ragnhild A
Abstract excerpt
BACKGROUND: The prevalence and clinical implications of genetic heterogeneity in patients with multiple colorectal liver metastases remain largely unknown. In a prospective series of patients undergoing resection of colorectal liver metastases, the aim was to investigate the inter-metastatic and primary-to-metastatic heterogeneity of mutations in KRAS, NRAS, BRAF, and PIK3CA and their prognostic impact. PATIENTS...
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